Reactivity Documentation
Bases, Strong |
mixed with |
Acyl Halides, Sulfonyl Halides, and Chloroformates |
Summary
- Corrosive: Reaction products may be corrosive
- Generates gas: Reaction liberates gaseous products and may cause pressurization
- Generates heat: Exothermic reaction at ambient temperatures (releases heat)
- Toxic: Reaction products may be toxic
-
May produce the following gases:
- Acid Fumes
- Base Fumes
- Hydrogen Halide
Details
Bases, Strong
is a reactive group.
Acyl Halides, Sulfonyl Halides, and Chloroformates
is a reactive group.
Reactivity Predictions (for each pair of reactive groups)
Bases, Strong
mixed with
Acyl Halides, Sulfonyl Halides, and Chloroformates
Acyl Halides, Sulfonyl Halides, and Chloroformates
Hazard Predictions
- Corrosive: Reaction products may be corrosive
- Generates gas: Reaction liberates gaseous products and may cause pressurization
- Generates heat: Exothermic reaction at ambient temperatures (releases heat)
- Toxic: Reaction products may be toxic
Acyl halides undergo rapid, exothermic nucleophilic attack by hydroxide ions, producing the corresponding carboxylic acid and a halide salt. If any water is present, it will also react with the acyl halide to generate carboxylic acid and HX gas, which can react with the remaining hydroxide (Loudon, Marc. 2002. Organic Chemistry. 4th ed. New York: Oxford University Press. p. 957-962).
Acetyl chloride reacts violently with strong bases (Pohanish, Richard P.; Greene, Stanley A. (2009). Wiley Guide to Chemical Incompatibilities (3rd Edition). John Wiley & Sons. p. 20).
Potential Gas Byproducts
- Acid Fumes
- Base Fumes
- Hydrogen Halide (HX)