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Reactivity Documentation

Bases, Strong

mixed with

Acyl Halides, Sulfonyl Halides, and Chloroformates

Summary

Details

Bases, Strong is a reactive group.

Reactivity Predictions (for each pair of reactive groups)

Bases, Strong mixed with
Acyl Halides, Sulfonyl Halides, and Chloroformates

Hazard Predictions

Acyl halides undergo rapid, exothermic nucleophilic attack by hydroxide ions, producing the corresponding carboxylic acid and a halide salt. If any water is present, it will also react with the acyl halide to generate carboxylic acid and HX gas, which can react with the remaining hydroxide (Loudon, Marc. 2002. Organic Chemistry. 4th ed. New York: Oxford University Press. p. 957-962).

Acetyl chloride reacts violently with strong bases (Pohanish, Richard P.; Greene, Stanley A. (2009). Wiley Guide to Chemical Incompatibilities (3rd Edition). John Wiley & Sons. p. 20).

Potential Gas Byproducts