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Hazard Predictions

• Corrosive: Reaction products may be corrosive
• Flammable: Reaction products may be flammable
• Generates heat: Exothermic reaction at ambient temperatures (releases heat)
• Intense or explosive reaction: Reaction may be particularly intense, violent, or explosive

One major method for preparing aryl-alkali metal compounds (such as organolithium reagents or Grignard reagents) involves the reaction of alkali metals with aryl halides. These products are highly basic and often pyrophoric, and the reaction is exothermic and can be dangerous if not controlled. Examples of specific incidents include:

Bromobenzene can explode if mixed with finely powdered lithium (Bretherick, L. 1996. Bretherick's Handbook of Reactive Chemical Hazards. Vol. 1, p. 1646. Fifth Ed. Urben, P.G., Ed. Butterworth-Heinemann, Boston, MA).

Chlorobenzene reacts exothermically with sodium wire to give sodium phenyl (Bretherick, L. 1996. Bretherick's Handbook of Reactive Chemical Hazards. Vol. 1, p. 1715. Fifth Ed. Urben, P.G., Ed. Butterworth-Heinemann, Boston, MA).