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Chemical Datasheet
Chemical Identifiers
CAS Number |
UN/NA Number |
DOT Hazard Label |
USCG CHRIS Code |
- 107-44-8
|
none
|
data unavailable
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none
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NIOSH Pocket Guide |
International Chem Safety Card |
none
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none
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NFPA 704
data unavailable
General Description
A chemical warfare nerve agent. A colorless, odorless liquid. Almost no odor in pure state.
Hazards
Reactivity Alerts
Air & Water Reactions
Hydrolyzed by water to form hydrogen fluoride and the nontoxic phosphonic acid derivative. It is rapidly hydrolyzed by dilute aqueous sodium hydroxide [Merck 11th ed. 1989].
Fire Hazard
For information on chemical warfare nerve agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Non-flammable. Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, it emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water. (EPA, 1998)
Health Hazard
For information on chemical warfare nerve agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Extremely toxic; lethal dose in humans may be as low as 0.01 mg/kg. Extremely active cholinesterase inhibitor. Toxic effects similar to, but more severe than those of parathion. Death within 15 minutes after fatal dose is absorbed. (EPA, 1998)
Reactivity Profile
Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, it emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water [EPA, 1998].
Belongs to the Following Reactive Group(s)
- Sulfonates, Phosphonates, and Thiophosphonates, Organic
- Acyl Halides, Sulfonyl Halides, and Chloroformates
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been
known to react with the
absorbents
listed below.
- Cellulose-Based Absorbents
- Mineral-Based & Clay-Based Absorbents
- Dirt/Earth
Response Recommendations
Isolation and Evacuation
For initial isolation and protective action distances for chemical warfare nerve agents see the Chemical Warfare Agents table in the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Firefighting
For information on chemical warfare nerve agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Protective clothing and respiratory protection.
Extinguish with foam, carbon dioxide, and dry chemical (EPA, 1998)
Non-Fire Response
For information on chemical warfare nerve agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Rapidly hydrolyzed by dilute aqueous sodium hydroxide or sodium carbonate forming relatively non-toxic products. Water alone removes the fluorine atom producing a non-toxic acid. Decontaminants include bleach slurry, dilute alkali, hot soapy water, steam and ammonia. (EPA, 1998)
Protective Clothing
For information on chemical warfare nerve agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem速 Suit Fabrics
Normalized Breakthrough Times (in Minutes)
Chemical |
CAS Number |
State |
QS |
QC |
SL |
C3 |
TF |
TP |
RC |
TK |
RF |
Sarin (GB), FINABEL 0.7.C |
107-44-8 |
Liquid |
|
|
|
|
&乙岳;1400� |
&乙岳;1400� |
|
|
|
Sarin (GB), MIL-STD-282 (10 g/m2) |
107-44-8 |
Liquid |
|
|
&乙岳;480� |
120� |
|
|
&乙岳;480� |
&乙岳;480� |
&乙岳;480� |
Sarin (GB), MIL-STD-282 (100 g/m2) |
107-44-8 |
Liquid |
|
|
|
|
&乙岳;480� |
&乙岳;480� |
&乙岳;480� |
&乙岳;480� |
&乙岳;480� |
Special Warning from DuPont: Tychem速 and Tyvek速 fabrics should not be
used around heat, flames, sparks or in potentially flammable or
explosive environments. Only...
(DuPont, 2024)
First Aid
For information on chemical warfare nerve agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Note: Sarin is an EXTREMELY ACTIVE cholinesterase inhibitor. Warning: Death may occur within 1 to 10 minutes of inhalation exposure to a minute amount of sarin. Immediate decontamination of the smallest drop is essential. Effects may be delayed with dermal exposure. Extreme caution is advised.
Signs and Symptoms of Sarin Exposure: The first indication of exposure to sarin may be a reaction at the point of contact: localized sweating, muscular twitching, and pinpoint eye pupils. Rhinorrhea (running nose), tightness of the chest with shortness of breath, and dimness of vision may be noted. In more severe exposure, headache, cramps, nausea, vomiting, involuntary defecation and urination, twitching, jerking, staggering, convulsions, drowsiness, coma, and respiratory arrest may be seen.
Emergency Life-Support Procedures: Acute exposure to sarin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to sarin.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists; use forced-oxygen mask. If breathing is labored, administer oxygen or other respiratory support.
4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to sarin.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists; use forced-oxygen mask.
4. Remove and isolate contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
6. Wash exposed skin areas thoroughly with commercial household liquid bleach and then flush with water. Avoid contacting the eyes or mouth with bleach.
7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists; use forced-oxygen mask. If breathing is labored, administer oxygen or other respiratory support.
2. RUSH to a health care facility!
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. DO NOT induce vomiting or attempt to neutralize.
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. (EPA, 1998)
Physical Properties
Flash Point:
Non-flammable
(EPA, 1998)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point:
-71属F
(EPA, 1998)
Vapor Pressure:
2.9 mmHg
at 77属F
(EPA, 1998)
Vapor Density (Relative to Air):
4.86
(EPA, 1998)
- Heavier than air; will sink
Specific Gravity:
1.1
at 68属F
(EPA, 1998)
- Denser than water; will sink
Boiling Point:
297属F
at 760 mmHg
(EPA, 1998)
Molecular Weight:
140.11
(EPA, 1998)
Water Solubility: data unavailable
Ionization Energy/Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
Final AEGLs for Agent GB (Sarin) (107-44-8)
Exposure Period |
AEGL-1 |
AEGL-2 |
AEGL-3 |
10 minutes |
0.0012 ppm |
0.015 ppm |
0.064 ppm |
30 minutes |
0.00068 ppm |
0.0085 ppm |
0.032 ppm |
60 minutes |
0.00048 ppm |
0.006 ppm |
0.022 ppm |
4 hours |
0.00024 ppm |
0.0029 ppm |
0.012 ppm |
8 hours |
0.00017 ppm |
0.0022 ppm |
0.0087 ppm |
(NAC/NRC, 2024)
ERPGs (Emergency Response Planning Guidelines)
No ERPG information available.
PACs (Protective Action Criteria)
Chemical |
PAC-1 |
PAC-2 |
PAC-3 |
Isopropyl methanefluoro-phosphonate; (Sarin; GB) (107-44-8)
|
0.00048 ppm |
0.006 ppm |
0.022 ppm |
(DOE, 2024)
Regulatory Information
EPA Consolidated List of Lists
Regulatory Name |
CAS Number/ 313 Category Code |
EPCRA 302 EHS TPQ |
EPCRA 304 EHS RQ |
CERCLA RQ |
EPCRA 313 TRI |
RCRA Code |
CAA 112(r) RMP TQ |
Sarin |
107-44-8 |
10 pounds |
10 pounds |
|
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|
|
(EPA List of Lists, 2024)
CISA Chemical Facility Anti-Terrorism Standards (CFATS)
|
RELEASE |
THEFT |
SABOTAGE |
Chemical of Interest |
CAS Number |
Min Conc |
STQ |
Security Issue |
Min Conc |
STQ |
Security Issue |
Min Conc |
STQ |
Security Issue |
Sarin; [o-Isopropyl methylphosphonofluoridate] |
107-44-8 |
|
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|
CUM 100 grams |
CW/CWP |
|
|
|
(CISA, 2007)
OSHA Process Safety Management (PSM) Standard List
Chemical Name |
CAS Number |
Threshold Quantity (TQ) |
Sarin |
107-44-8 |
100 pounds |
(OSHA, 2019)
Alternate Chemical Names
- GB (CHEMICAL WARFARE AGENT)
- IMPF
- ISOPROPOXYMETHYLPHOSPHORYL FLUORIDE
- ISOPROPYL METHANEFLUOROPHOSPHONATE
- ISOPROPYL METHYLFLUOROPHOSPHATE
- ISOPROPYL METHYLFLUOROPHOSPHONATE
- ISOPROPYL METHYLPHOSPHONOFLUORIDATE
- ISOPROPYL-METHYL-PHOSPHORYL FLUORIDE
- 1-METHYLETHYL METHYLPHOSPHONOFLUORIDATE
- METHYLFLUOROPHOSPHORIC ACID ISOPROPYL ESTER
- METHYLPHOSPHONOFLUORIDIC ACID ISOPROPYL ESTER
- MFI
- O-ISOPROPYL METHYLFLUOROPHOSPHONATE
- O-ISOPROPYL METHYLPHOSPHONOFLUORIDATE
- PHOSPHINE OXIDE, FLUOROISOPROPOXYMETHYL
- PHOSPHONOFLUORIDIC ACID, METHYL-, ISOPROPYL ESTER
- PHOSPHORIC ACID, METHYLFLUORO-, ISOPROPYL ESTER
- SARIN
- SARIN II
- T-144
- T-2106
- TL 1618
- TRILONE 46